Synergistic Antiangiogenic Effects of Stathmin Inhibition and Taxol Exposure
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چکیده
منابع مشابه
Synergistic antiangiogenic effects of stathmin inhibition and taxol exposure.
Stathmin is one of the key regulators of the microtubule cytoskeleton and the mitotic spindle in eukaryotic cells. It is expressed at high levels in a wide variety of human cancers and may provide an attractive target for cancer therapy. We had previously shown that stathmin inhibition results in the abrogation of the malignant phenotype. The microtubule-interfering drug, taxol, has both antitu...
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Stathmin is an abundant cytosolic phosphoprotein that plays an important role in the regulation of cellular proliferation. Its major function is to promote depolymerization of the microtubules that make up the mitotic spindle. Taxol is an effective chemotherapeutic agent whose activity is mediated through stabilization of the microtubules of the mitotic spindle. We demonstrate that antisense in...
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Limitations of prostate cancer therapy may be overcome by combinations of chemotherapeutic agents with gene therapy directed against specific proteins critical for disease progression. Stathmin is overexpressed in many types of human cancer, including prostate cancer. Stathmin is one of the key regulators of the microtubule network and the mitotic spindle and provides an attractive therapeutic ...
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ژورنال
عنوان ژورنال: Molecular Cancer Research
سال: 2007
ISSN: 1541-7786,1557-3125
DOI: 10.1158/1541-7786.mcr-06-0290